Gene Expression and Antioxidant Effects of Cinnamon (Cinnamomum Zeylanicum, Breyne) in Alloxan -Induced Diabetic Rats

Background and Aim: In this study rats, a systematic analysis was conducted to examine the antioxidantproperties of cinnamon (Cinnamomum Zeylanicum, Breyne) in controlling high blood sugar levels, apharmacological comparison made investigate whether or not it had positive effect on antioxidantsystem.Materials Methods: Alloxan 60 mg injected into marginal ear veins eighteen diabetic rats Afterthis animal study, were randomly assigned 4 groups. There six animals each ofthe groups: Group 1(C): Positive control, Received orally 5 ml normal saline (0.9% NaCl) daily. Group2(D): Negative Diabetes only, received single-dose alloxan mg/kg body weight. Group3(K): 35 weight dissolved 2 normal. 4(I):Diabetes given I.U/ insulin subcutaneously daily.Results: All groups treated for four weeks.Blood samples taken from these weeklyfor biochemical estimate: Blood glucose malondialdehyde(MDA), Glutathione (GSH). Theresults showed MDA concentration associated with an increased oxidant stress alloxaninduces animals. The statistical that significant (P<0.05) reductionin glucose, MDA,GSH control. level MDA, GSH also significantlyreduced all period before Cinnamon extract .there was4.3-fold more Ins I upregulated -treated percent control group wereheterozygous three experimental mutant trait.Conclusion: Furthermore, Cinnamon-treated (group K) increase inthe activities both enzymatic non-enzymatic antioxidants concomitant overexpression ofinsulin genes when compared D). contains andantihyperglycemic effects at end experiment.